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mouse kidney epithelial cell line  (ATCC)
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ATCC mouse kidney epithelial cell line
The mechanism diagram of the study. Upregulated ATF3 in damaged tubular <t>epithelial</t> cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.
Mouse Kidney Epithelial Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse kidney epithelial cell line/product/ATCC
Average 96 stars, based on 1 article reviews
mouse kidney epithelial cell line - by Bioz Stars, 2026-06
96/100 stars
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tcmk 1 mouse kidney tubule epithelial cell line  (ATCC)
96
ATCC tcmk 1 mouse kidney tubule epithelial cell line
The mechanism diagram of the study. Upregulated ATF3 in damaged tubular <t>epithelial</t> cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.
Tcmk 1 Mouse Kidney Tubule Epithelial Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tcmk 1 mouse kidney tubule epithelial cell line/product/ATCC
Average 96 stars, based on 1 article reviews
tcmk 1 mouse kidney tubule epithelial cell line - by Bioz Stars, 2026-06
96/100 stars
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mouse epithelial kidney cell line tcmk 1  (ATCC)
96
ATCC mouse epithelial kidney cell line tcmk 1
The mechanism diagram of the study. Upregulated ATF3 in damaged tubular <t>epithelial</t> cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.
Mouse Epithelial Kidney Cell Line Tcmk 1, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse epithelial kidney cell line tcmk 1/product/ATCC
Average 96 stars, based on 1 article reviews
mouse epithelial kidney cell line tcmk 1 - by Bioz Stars, 2026-06
96/100 stars
  Buy from Supplier
mouse kidney epithelial tcmk 1 cell line  (ATCC)
96
ATCC mouse kidney epithelial tcmk 1 cell line
The mechanism diagram of the study. Upregulated ATF3 in damaged tubular <t>epithelial</t> cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.
Mouse Kidney Epithelial Tcmk 1 Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse kidney epithelial tcmk 1 cell line/product/ATCC
Average 96 stars, based on 1 article reviews
mouse kidney epithelial tcmk 1 cell line - by Bioz Stars, 2026-06
96/100 stars
  Buy from Supplier
mouse kidney tubular epithelial cell line  (ATCC)
96
ATCC mouse kidney tubular epithelial cell line
The mechanism diagram of the study. Upregulated ATF3 in damaged tubular <t>epithelial</t> cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.
Mouse Kidney Tubular Epithelial Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse kidney tubular epithelial cell line/product/ATCC
Average 96 stars, based on 1 article reviews
mouse kidney tubular epithelial cell line - by Bioz Stars, 2026-06
96/100 stars
  Buy from Supplier
mouse kidney epithelial cell line tcmk 1  (ATCC)
96
ATCC mouse kidney epithelial cell line tcmk 1
The mechanism diagram of the study. Upregulated ATF3 in damaged tubular <t>epithelial</t> cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.
Mouse Kidney Epithelial Cell Line Tcmk 1, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse kidney epithelial cell line tcmk 1/product/ATCC
Average 96 stars, based on 1 article reviews
mouse kidney epithelial cell line tcmk 1 - by Bioz Stars, 2026-06
96/100 stars
  Buy from Supplier

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The mechanism diagram of the study. Upregulated ATF3 in damaged tubular epithelial cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.

Journal: International Journal of Biological Sciences

Article Title: ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming

doi: 10.7150/ijbs.125062

Figure Lengend Snippet: The mechanism diagram of the study. Upregulated ATF3 in damaged tubular epithelial cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.

Article Snippet: Mouse kidney epithelial cell line (TCMK-1), HEK 293T cells and rat renal interstitial fibroblasts (NRK-49F) cells were purchased from the American Type Culture Collection (Manassas, VA) and were cultured in DMEM (Sigma-Aldrich) containing 10% fetal bovine serum (FBS), at 37°C, 5% CO2, 95% air.

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